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After 108 weeks, changes in UACR from baseline with lixisenatide were 1.69% [(95% CI: 11.69 to 8.30), p=0.7398] in patients with normoalbuminuria, 21.10% [(95% CI: 42.25 to 0.04), p=0.0502] in patients with microalbuminuria, and 39.18% [(95% CI: 6853 to 984), p=0.0070] in patients with macroalbuminuria

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Observational signals in people with diabetes are encouraging but do not prove cause

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Cellular damage caused by oxidative stress can release autoantigens and activate an autoimmune response, contributing to melanocyte destruction.4,28,67,68 Former studies have shown elevated levels of oxidative stress biomarkers, such as malondialdehyde (MDA), and decreased antioxidants, such as superoxide dismutase (SOD) and catalase, in both affected skin and blood of patients